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Research Mission

Our laboratory includes basic science and translational research with 2 main areas of interest:

  • understanding nasal epithelium in health and disease, and
  • promoting upper airway mucosal regeneration in response to injury from surgery, chemicals, and toxins in human and animal model systems. 

Out research also includes understanding nasal immune system dysfunctions in patients with chronic diseases such as cystic fibrosis and rhinosinusitis

The ultimate goal of our efforts is to more effectively treat debilitating inflammatory sinus disorders, particularly with regard to empty nose syndrome (ENS) and to create functional respiratory mucosal issue grafts/lining material to address upper (nasal) and lower (pulmonary) airway diseases

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Nayak Research Lab, 2019

Nayak Lab Group Photo 2019

CIRM Award

In 2017, we received a CIRM award as part of a Stanford collaborative cystic fibrosis gene editing group with $2.2 million to advance the use of CRISPR technology to perform genome correction of the CFTR chloride transport mutations in airway stem cells.

Our Funding and Support

CA Institute of Regenerative Medicine (CIRM) 2017-2019 Co-I with Drs. Matthew Porteus, Calvin Kuo, Tushar Desai

Philanthropic Support: Anonymous Donor Support

NIH/Cooperative Centers for Translational Research on Human Immunology and Biodefense (CCHI)

CCHI – “Influenza virus tropism for human nasal epithelial basal cells of the upper airway.”

Featured Article

High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia

Vaidyanathan, Sriram et al.
Cell Stem Cell, Volume 26, Issue 2, 161 – 171.e4