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Our Research

Our laboratory includes basic science and translational research with two main areas of interest:

  • understanding the nasal epithelium in health and disease, and
  • promoting upper airway mucosal regeneration in response to injury from surgery, chemicals, and toxins in human and animal model systems.

Our research also includes understanding nasal immune system dysfunction in patients with chronic diseases such as cystic fibrosis and rhinosinusitis.

CIRM Award

In 2017, we received a CIRM award as part of a Stanford collaborative cystic fibrosis gene editing group with $2.2 million to advance the use of CRISPR technology to perform genome correction of the CFTR chloride transport mutations in airway stem cells.

Research Goal

The ultimate goal of our efforts is to more effectively treat debilitating inflammatory sinus disorders, particularly with regard to empty nose syndrome (ENS) and to create functional respiratory mucosal tissue grafts/lining material to address upper (nasal) and lower (pulmonary) airway diseases.

Research Topics

Immunology : Immune Systems and Immunity
Stem Cell / Regenerative Medicine for Upper Airway Diseases
Empty Nose Syndrome and Upper Airway Physiology
Clinical / Translational Research

Our Funding and Support

CA Institute of Regenerative Medicine (CIRM) 2017-2019 Co-I with Drs. Matthew Porteus, Calvin Kuo, Tushar Desai

Philanthropic Support: Anonymous Donor Support

NIH/Cooperative Centers for Translational Research on Human Immunology and Biodefense (CCHI)

CCHI – “Influenza virus tropism for human nasal epithelial basal cells of the upper airway.”