Immunology: Immune Systems and Immunity

The innate and adaptive immunologic microenvironment in chronic human upper airway diseases like chronic rhinosinusitis (CRS) has also been of ongoing interest of our group. We have shown altered levels of cytokines, oxidases, and Tregs in CRS patients and recently, through collaboration with Drs. Bruce Tan and Robert Schleimer at Northwestern University, IgD+ B cell populations that are selectively recruited into the chronically inflamed tissue beds within the upper airway. Our findings underscore numerous attractive opportunities to better understand immune dysregulation in the human upper airway.

Publications

Lee, Ivan T., Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev, Sizun Jiang, Phillip A. Gall, Chun-Kang Liao, et al. “Robust ACE2 Protein Expression Localizes to the Motile Cilia of the Respiratory Tract Epithelia and Is Not Increased by ACE Inhibitors or Angiotensin Receptor Blockers.” MedRxiv, May 12, 2020, 2020.05.08.20092866. https://doi.org/10.1101/2020.05.08.20092866.
Huang, Zhenxiao, Nathalia Velasquez, Alan Nguyen, Ting Ye, Wei Le, Dawn T. Bravo, Peter H. Hwang, Bing Zhou, and Jayakar V. Nayak. “Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium.” American Journal of Rhinology & Allergy 33, no. 3 (2019): 277–85. https://doi.org/10.1177/1945892418823305.
Kim, Young Hyo, Tsuguhisa Nakayama, and Jayakar Nayak. “Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation.” Allergy, Asthma & Immunology Research 10, no. 1 (2018): 6. https://doi.org/10.4168/aair.2018.10.1.6.
Huang, Zhenxiao, Jayakar V. Nayak, Yan Sun, Qian Huang, and Bing Zhou. “Peripheral Blood T-Helper Cells and Eosinophil Populations in Patients with Atopic and Nonatopic Chronic Rhinosinusitis:” American Journal of Rhinology & Allergy, January 1, 2017. https://doi.org/10.2500/ajra.2017.31.4405.
Min, Jin-Young, Jayakar V. Nayak, Kathryn E. Hulse, Whitney W. Stevens, Paul A. Raju, Julia H. Huang, Lydia A. Suh, et al. “Evidence for Altered Levels of IgD in the Nasal Airway Mucosa of Patients with Chronic Rhinosinusitis.” Journal of Allergy and Clinical Immunology 140, no. 6 (2017): 1562-1571.e5. https://doi.org/10.1016/j.jaci.2017.05.032.
Edward, Justin A, Mrinmoy Sanyal, Wei Le, Ethan Soudry, Vijay R Ramakrishnan, Dawn T Bravo, Alan L Nguyen, et al. “Selective Expansion of Human Regulatory T Cells in Nasal Polyps, and Not Adjacent Tissue Microenvironments, in Individual Patients Exposed to Steroids.” Clinical Immunology 179 (2017): 66–76. https://doi.org/10.1016/j.clim.2017.02.002.
Böscke, Robert, Eszter K. Vladar, Michael Könnecke, Birgit Hüsing, Robert Linke, Ralph Pries, Norbert Reiling, Jeffrey D. Axelrod, Jayakar V. Nayak, and Barbara Wollenberg. “Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps.” American Journal of Respiratory Cell and Molecular Biology 56, no. 5 (2017): 575–84. https://doi.org/10.1165/rcmb.2016-0024OC.
Rashan, Ali R., Eliver Goshn, Asa Peterson, Yang Yang, Meghan Phillips, Bita Sahaf, Leonore Herzenberg, and Jayakar V. Nayak. “Characterization of Immunoglobulin E Plasma Cells That Are Elevated in the Upper Airway Mucosa of Nonatopic Patients with Chronic Rhinosinusitis without Nasal Polyps: IgE Plasmablasts in Nonatopic CRSsNP.” International Forum of Allergy & Rhinology 6, no. 4 (2016): 378–84. https://doi.org/10.1002/alr.21696.
Cho, Do-Yeon, Wei Le, Dawn T. Bravo, Peter H. Hwang, Beate Illek, Horst Fischer, and Jayakar V. Nayak. “Air Pollutants Cause Release of Hydrogen Peroxide and Interleukin-8 in a Human Primary Nasal Tissue Culture Model: PM Induced Oxidative Stress in Nasal Tissue.” International Forum of Allergy & Rhinology 4, no. 12 (2014): 966–71. https://doi.org/10.1002/alr.21413.
Edward, Justin A., Mrinmoy Sanyal, Vijay R. Ramakrishnan, Wei Le, Alan L. Nguyen, Todd T. Kingdom, Peter H. Hwang, and Jayakar V. Nayak. “Systemic Prednisone Administration Selectively Alters Granulocyte Subsets in Nasal Polyps from Aspirin-Exacerbated Respiratory Disease and Chronic Rhinosinusitis Patients: Prednisone Alters Granulocytes in Nasal Polyps.” International Forum of Allergy & Rhinology 3, no. 11 (2013): 866–76. https://doi.org/10.1002/alr.21221.
Cho, Do-Yeon, Jayakar V. Nayak, Dawn T. Bravo, Wei Le, Alan Nguyen, Justin A. Edward, Peter H. Hwang, Beate Illek, and Horst Fischer. “Expression of Dual Oxidases and Secreted Cytokines in Chronic Rhinosinusitis: DUOX1/DUOX2 and Secreted Cytokines in CRS.” International Forum of Allergy & Rhinology 3, no. 5 (2013): 376–83. https://doi.org/10.1002/alr.21133.
Figures, Mindy R., Jayakar V. Nayak, Carl Gable, and Alexander G. Chiu. “Sinonasal Seromucinous Hamartomas: Clinical Features and Diagnostic Dilemma.” Otolaryngology–Head and Neck Surgery 143, no. 1 (2010): 165–66. https://doi.org/10.1016/j.otohns.2009.11.014.
Cohen, Michael, Jennifer Kofonow, Jayakar V. Nayak, James N. Palmer, Alexander G. Chiu, Jeff G. Leid, and Noam A. Cohen. “Biofilms in Chronic Rhinosinusitis: A Review.” American Journal of Rhinology & Allergy 23, no. 3 (2009): 255–60. https://doi.org/10.2500/ajra.2009.23.3319.
Nayak, Jayakar V., David A. Hokey, Adriana Larregina, Yukai He, Russell D. Salter, Simon C. Watkins, and Louis D. Falo. “Phagocytosis Induces Lysosome Remodeling and Regulated Presentation of Particulate Antigens by Activated Dendritic Cells.” The Journal of Immunology 177, no. 12 (December 15, 2006): 8493–8503. https://doi.org/10.4049/jimmunol.177.12.8493.
López-Albaitero, Andrés, Jayakar V. Nayak, Takeshi Ogino, Avinash Machandia, William Gooding, Albert B. DeLeo, Soldano Ferrone, and Robert L. Ferris. “Role of Antigen-Processing Machinery in the In Vitro Resistance of Squamous Cell Carcinoma of the Head and Neck Cells to Recognition by CTL.” The Journal of Immunology 176, no. 6 (March 15, 2006): 3402–9. https://doi.org/10.4049/jimmunol.176.6.3402.
Yu, Paul B., William Parker, Jayakar V. Nayak, and Jeffrey L. Platt. “Sensitization with Xenogeneic Tissues Alters the Heavy Chain Repertoire of Human Anti-Gal??1???3Gal Antibodies:” Transplantation 80, no. 1 (2005): 102–9. https://doi.org/10.1097/01.TP.0000162976.07023.6D.
Dileo, John, Rajkumar Banerjee, Mark Whitmore, Jayakar V Nayak, Louis D Falo, and Leaf Huang. “Lipid–Protamine–DNA-Mediated Antigen Delivery to Antigen-Presenting Cells Results in Enhanced Anti-Tumor Immune Responses.” Molecular Therapy 7, no. 5 (2003): 640–48. https://doi.org/10.1016/S1525-0016(03)00064-9.