Immunology: Immune Systems and Immunity
The innate and adaptive immunologic microenvironment in chronic human upper airway diseases like chronic rhinosinusitis (CRS) has also been of ongoing interest of our group. We have shown altered levels of cytokines, oxidases, and Tregs in CRS patients and recently, through collaboration with Drs. Bruce Tan and Robert Schleimer at Northwestern University, IgD+ B cell populations that are selectively recruited into the chronically inflamed tissue beds within the upper airway. Our findings underscore numerous attractive opportunities to better understand immune dysregulation in the human upper airway.